1,3-Di-o-tolylguanidine

1,3-Di-o-tolylguanidine (DTG) is a sigma (sigma) receptor ligand (Kis = 61 and 42 nM for sigma1 and sigma2 receptors, respectively). In vivo, DTG (10, 15, and 20 mg/kg, i.p.) increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice. It decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).Formal Name: N,N'-bis(2-methylphenyl)-guanidine. CAS Number: 97-39-2. Synonyms: DTG, NSC 132023, NSC 473. Molecular Formula: C15H17N3. Formula Weight: 239.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. SMILES: CC1=CC=CC=C1NC(NC2=CC=CC=C2C)=N. InChi Code: InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18). InChi Key: OPNUROKCUBTKLF-UHFFFAOYSA-N.