1,2,3,4-Tetrahydro-beta-carboline

1,2,3,4-Tetrahydro-beta-carboline is a serotonin reuptake inhibitor (IC50 = 7.4 µM in rat brain homogenates) and metabolite of tryptamine (Cay-20995). In vivo, 1,2,3,4-tetrahydro-beta-carboline (20 and 40 µg/animal, i.c.v.) reduces serotonin levels in rat forebrain. It induces serotonin-mediated hyperactivity syndrome (HHS) in rats (ED50 = 48 mg/kg). 1,2,3,4-Tetrahydro-beta-carboline (6.25-75 mg/kg) also reduces acetic acid-induced writhing in rats.Formal Name: 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole. CAS Number: 16502-01-5. Synonyms: Tetrahydronorharman, Tetrahydro-beta-carboline, THBC, Tryptoline. Molecular Formula: C11H12N2. Formula Weight: 172.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml. lambdamax: 221 nm. SMILES: C1(C=CC=C2)=C2C(CCNC3)=C3N1. InChi Code: InChI=1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2. InChi Key: CFTOTSJVQRFXOF-UHFFFAOYSA-N.