1,10-Phenanthroline (hydrate)

1,10-Phenanthrine is a metal chelator and inhibitor of metalloproteases. It inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin. 1,10-Phenanthrine is fungistatic against P. verrucosa (MIC = 0.8 µg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner. It induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs in vitro when used at concentrations ranging from 0.5 to 150 µM. 1,10-Phenanthrine (20 mg/kg per day) reduces worm burden in a mouse model of S. mansoni infection.CAS Number: 5144-89-8. Synonyms: o-Phenanthroline. Molecular Formula: C12H8N2 . H2O. Formula Weight: 198.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 226, 230, 264 nm. SMILES: C12=CC=C3C(N=CC=C3)=C1N=CC=C2.O. InChi Code: InChI=1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1,/h1-8H,1H2. InChi Key: PPQJCISYYXZCAE-UHFFFAOYSA-N.