Tobramycin

Tobramycin is an aminoglycoside antibiotic. It binds to the 30S ribosomal subunit, inhibiting protein synthesis. Tobramycin is active against a variety of Gram-positive and Gram-negative bacteria, including several strains of S. aureus, P. aeruginosa, E. coli, K. pneumoniae, and Enterobacter (mean MICs = 0.2, 0.6, 1.2, 0.8, and 0.8 µg/ml, respectively). It reduces the number of colony forming units (CFUs) in several mouse models of thigh infection. Formulations containing tobramycin have been used in the treatment of Gram-positive and Gram-negative bacterial infections.Formal Name: O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1->4)]-2-deoxy-D-streptamine. CAS Number: 32986-56-4. Synonyms: Deoxykanamycin B, Distobram, Gernebcin, NSC 180514. Molecular Formula: C18H37N5O9. Formula Weight: 467.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: N[C@@H]1[C@@H](O[C@]2([H])[C@H](N)C[C@H](O)[C@@H](CN)O2)[C@H](O)[C@@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C1. InChi Code: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1. InChi Key: NLVFBUXFDBBNBW-PBSUHMDJSA-N.