Tedizolid

Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate (Cay-23729). Tedizolid phosphate is converted to tedizolid by phosphatases in vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistant S. aureus (MRSA), E. faecalis, and penicillin-susceptible S. pneumoniae (MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptible S. aureus (MSSA) infection (ED50 = 8.8 mg/kg).Formal Name: (5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone. CAS Number: 856866-72-3. Synonyms: DA 7157, TR-700. Molecular Formula: C17H15FN6O3. Formula Weight: 370.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble, Ethanol: slightly soluble. lambdamax: 234, 302 nm. SMILES: FC1=C(C2=CN=C(C3=NN(C)N=N3)C=C2)C=CC(N4C[C@H](CO)OC4=O)=C1. InChi Code: InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1. InChi Key: XFALPSLJIHVRKE-GFCCVEGCSA-N.