Sulbactam

beta-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams. Resistance against beta-lactam antibiotics can result from the production of beta-lactamases, which is a common mechanism employed by Gram-negative bacteria. Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of beta-lactamases. It is effective against a wide variety of serine beta-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes. However, it is not effective against metallo-beta-lactamases, cephalosporinases, or oxacillinases.Formal Name: (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 4,4-dioxide. CAS Number: 68373-14-8. Synonyms: CP 45,899, Penicillanic Acid Dioxide. Molecular Formula: C8H11NO5S. Formula Weight: 233.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: O=C(C1)N2[C@]1([H])S(C(C)(C)[C@@H]2C(O)=O)(=O)=O. InChi Code: InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1. InChi Key: FKENQMMABCRJMK-RITPCOANSA-N.