Sitafloxacin

Sitafloxacin is a fluoroquinolone antibiotic. It is active against a panel of clinical isolates from a variety of bacterial species (MIC50s = =0.006-1.56 µg/ml), including methicillin-resistant strains of S. aureus and S. epidermidis and ofloxacin-resistant P. aeruginosa (MIC50s = 0.025-6.25 µg/ml). Sitafloxacin inhibits S. pneumoniae DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation (IC50s = 4.38 and 3.12 mg/L, respectively) and M. tuberculosis DNA gyrase supercoiling activity (IC50 = 1.67 mg/L). It decreases the number of colony forming units (CFUs) in the lung and spleen in a mouse model of M. avium infection.Formal Name: 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. CAS Number: 127254-12-0. Synonyms: DU6859a, DU-6859. Molecular Formula: C19H18ClF2N3O3. Formula Weight: 409.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble, Methanol: slightly soluble. lambdamax: 296 nm. SMILES: FC1=C(N2C[C@@H](N)C3(CC3)C2)C(Cl)=C4C(C(C(C(O)=O)=CN4[C@H]5[C@@H](F)C5)=O)=C1. InChi Code: InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1. InChi Key: PNUZDKCDAWUEGK-CYZMBNFOSA-N.