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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay23479-5 | 5 mg | - |
6 - 10 business days* |
166.00€
|
|||
Cay23479-25 | 25 mg | - |
6 - 10 business days* |
578.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Rolitetracycline is a tetracycline antibiotic with bacteriostatic activity at low concentrations... more
Product information "Rolitetracycline"
Rolitetracycline is a tetracycline antibiotic with bacteriostatic activity at low concentrations (7.8 µg/ml) and bactericidal activity at high concentrations (15.6 µg/ml) against E. coli. It has additive and synergistic effects with penicillin and cephalothin, respectively, in vitro against 34 E. coli and S. aureus strains. Rolitetracycline is also active against P. falciparum strains (IC50s = 45-208 µM) that are susceptible and resistant to chloroquine (Cay-14194). It also reduces amyloid-beta (1-40) (Abeta40) fibrilization (IC50 = 59 µM in an immune assay) and completely inhibits Abeta40-induced cellular toxicity at a concentration of 20 µM.Formal Name: 4-(dimethylamino)-1,4S,4aS,5,5aS,6S,11,12aS-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide. CAS Number: 751-97-3. Synonyms: Pyrrolidinylmethyltetracycline, SQ 15,659. Molecular Formula: C27H33N3O8. Formula Weight: 527.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. lambdamax: 219, 267, 365 nm. SMILES: OC([C@@](C(C(C(NCN1CCCC1)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C3)=C([C@@]3([H])[C@@]4(O)C)C(C5=C4C=CC=C5O)=O. InChi Code: InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1. InChi Key: HMEYVGGHISAPJR-IAHYZSEUSA-N.
Keywords: | Pyrrolidinylmethyltetracycline, SQ 15,659, 4-(dimethylamino)-1,4S,4aS,5,5aS,6S,11,12aS-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 23479 |
Properties
Application: | Antibacterial, Protein biosynthesis inhibitor |
MW: | 527.6 D |
Formula: | C27H33N3O8 |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 751-97-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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