Puromycin Aminonucleoside (3'-Dimethylamino-3'-deoxyadenosine)

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin lacking the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis but exhibits antitumor properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing expression of integrin expression in cultured glomerular epithelial cells.. Source: Streptomyces alboniger, Semi-synthetic , Apperance: White powder, , Solubility: Soluble in water. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.