PNU 100480

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid (Cay-20378), rifampin (rifampicin, Cay-14423), ethambutol (Cay-23713), and streptomycin (Cay-21211, MICs = =0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 µg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.Formal Name: N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide. CAS Number: 168828-58-8. Synonyms: Sutezolid, U 100480. Molecular Formula: C16H20FN3O3S. Formula Weight: 353.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3mg/mL, DMSO: 10mg/mL, DMSO:PBS (pH 7.2) (1:6): 0.14mg/mL. lambdamax: 205, 259 nm. SMILES: CC(NC[C@@H](CN1C2=CC=C(N3CCSCC3)C(F)=C2)OC1=O)=O. InChi Code: InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1. InChi Key: FNDDDNOJWPQCBZ-ZDUSSCGKSA-N.