Nitrofurantoin

Nitrofurantoin is an antibiotic. In vivo, nitrofurantoin (25-100 mg/kg, i.m.) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection. Formulations containing nitrofurantoin have been used to treat urinary tract infections.Formal Name: 1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione. CAS Number: 67-20-9. Synonyms: NSC 2107, NSC 44150. Molecular Formula: C8H6N4O5. Formula Weight: 238.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.5 mg/ml, Ethanol: 15 mg/ml. lambdamax: 268, 363 nm. SMILES: O=C(NC(C1)=O)N1/N=C/C2=CC=C([N+]([O-])=O)O2. InChi Code: InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+. InChi Key: NXFQHRVNIOXGAQ-YCRREMRBSA-N.