Mycophenolic Acid (Melbex, Lilly 68618, NSC 129185)

Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation has shown mycophenolic acid to display a broad range of pharmacological activities including antitumor, antiviral, antifungal and antiprotozoan activities. However, it was the discovery that mycophenolic acid was a potent immunosuppressant, useful to prevent kidney transplant rejection, that led to its commercial development and that of related semi-synthetics as pharmaceuticals. Mycophenolic acid acts by inihibition of inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in the proliferation of B and T lymphocytes. Source: Penicillium sp. MST-FP1988 , Apperance: White solid, Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility , Storage and Stability:, May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.