Minocycline (hydrochloride hydrate)

Minocycline is a broad-spectrum tetracycline antibiotic. It is active against E. faecium in vitro (MIC = 16 mg/L). Minocycline (20 mg/kg every 12 hours) reduces the number of bacteria in the lung in a mouse model of multidrug resistant A. baumannii-induced pneumonia. It reduces spinal cord lesion size and improves hindlimb function post-injury in a mouse model of acute spinal cord injury when administered at an initial dose of 50 mg/kg and subsequent doses of 25 mg/kg per day for 5 days. Formulations containing minocycline have been used in the treatment of acne vulgaris.Formal Name: (4S,12aS)-4,7-bis(dimethylamino)-1,4,4aS,5,5aR,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride, hydrate. Synonyms: NSC 141993. Molecular Formula: C23H27N3O7 . HCl [XH2O]. Formula Weight: 493.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 1mg/ml*. lambdamax: 257, 342 nm. SMILES: NC(C1=C(O)[C@@H](N(C)C)[C@@]2([H])[C@](C1=O)(O)C(O)=C3C(C4=C(O)C=CC(N(C)C)=C4C[C@@]3([H])C2)=O)=O.Cl.O. InChi Code: InChI=1S/C23H27N3O7.ClH.H2O/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28,,/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32),1H,1H2/t9-,11-,17-,23-,,/m0../s1. InChi Key: HDRFYBRHRCRYQB-QVVXJPBESA-N.