Lincomycin

Lincomycin is a lincosamide antibiotic originally isolated from S. lincolnensis. It is active against Gram-positive bacteria, including various strains of S. aureus, S. epidermidis, S. pneumoniae, and S. pyogenes (MICs = 0.2-3.2, 0.4-1.8, 0.01-0.8, and 0.04-0.8 µg/ml, respectively). Lincomycin selectively inhibits protein synthesis in purified ribosomes from S. aureus over E. coli (IC50s = 0.03 and 1.7 µg/ml, respectively, in cell-free assays). It is protective against development of mastitis in a mouse model of acute mastitis induced by S. aureus with a 50% protective dose (PD50) value of 3.5 mg/kg. Formulations containing lincomycin have been used in the treatment of Gram-positive bacterial infections.Formal Name: methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside. CAS Number: 154-21-2. Synonyms: U-10149. Molecular Formula: C18H34N2O6S. Formula Weight: 406.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: C[C@@H](O)[C@](NC([C@@H]1C[C@@H](CCC)CN1C)=O)([H])[C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O. InChi Code: InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1. InChi Key: OJMMVQQUTAEWLP-KIDUDLJLSA-N. Origin: Synthetic.