Josamycin

Josamycin is a macrolide antibiotic originally isolated from S. narbonensis. It is active against clinical isolates of the Gram-positive aerobic bacteria S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, and S. agalactiae (MIC50s = =0.39 µg/ml for all), as well as the Gram-negative anaerobic bacteria Peptococcus, Peptostreptococcus, and Clostridium when used at concentrations of 6.25 µg/ml. It increases survival in mouse models of systemic S. aureus, S. pyogenes, and S. pneumoniae infection with ED50 values of 206.8, 205, and 86.7 mg/kg, respectively.Formal Name: 3-acetate 4B-(3-methylbutanoate) leucomycin V. CAS Number: 16846-24-5. Synonyms: Kitasamycin A3, Leucomycin A3, Turimycin A5. Molecular Formula: C42H69NO15. Formula Weight: 828.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 231 nm. SMILES: CO[C@@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@](O)(C)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(C[C@H]1OC(C)=O)=O. InChi Code: InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1. InChi Key: XJSFLOJWULLJQS-NGVXBBESSA-N. Origin: Bacterium/Streptomyces narbonensis var. josamyceticus var. nova.