Gamithromycin

Gamithromycin is an antibiotic that is active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 µg/ml, respectively). It reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg. Formulations containing gamithromycin have been used to treat bovine respiratory diseases.Formal Name: (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one. CAS Number: 145435-72-9. Synonyms: ML-1709460. Molecular Formula: C40H76N2O12. Formula Weight: 777.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 5 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: CN(C)[C@@H](C[C@@H](C)O1)[C@@H](O)[C@]1([H])O[C@H]2[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC([C@H](C)[C@@H](O[C@@]3([H])C[C@](OC)(C)[C@@H](O)[C@H](C)O3)[C@@H]2C)=O. InChi Code: InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1. InChi Key: VWAMTBXLZPEDQO-UZSBJOJWSA-N.