Flumequine

Flumequine is a fluoroquinolone antibiotic. It is active against S. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, and K. pneumoniae (MICs = 1-100 µg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 µg/ml). It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication. In vivo, flumequine (50 mg/kg) increases survival in rat models of P. vulgaris-induced urinary tract infection and P. mirabilis-induced prostatitis. Formulations containing flumequine have been used in the treatment of urinary tract infections in veterinary medicine.Formal Name: 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid. CAS Number: 42835-25-6. Synonyms: (±)-Flumequine, R-802. Molecular Formula: C14H12FNO3. Formula Weight: 261.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 219, 230, 249, 325, 338 nm. SMILES: FC1=CC(CCC(C)N2C=C(C(O)=O)C3=O)=C2C3=C1. InChi Code: InChI=1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19). InChi Key: DPSPPJIUMHPXMA-UHFFFAOYSA-N.