Fidaxomycin

Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 µM, respectively). It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml). Orally administered fidaxomycin exhibits minimal systemic bioavailability resulting in maximal gastrointestinal tract distribution. Fidaxomycin is effective in clearing C. difficile infections while sparing Gram-negative bacteria in the gut.Formal Name: (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-beta-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-beta-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one. CAS Number: 873857-62-6. Synonyms: Clostomicin B1, Lipiarmycin, OPT-80, PAR-101, Tiacumicin B. Molecular Formula: C52H74Cl2O18. Formula Weight: 1058.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 230, 268 nm. SMILES: O=C1/C(CO[C@H]2[C@@H](OC)[C@@H](O)[C@H](OC(C3=C(CC)C(Cl)=C(O)C(Cl)=C3O)=O)[C@@H](C)O2)=C/C=C/C[C@H](O)/C(C)=C\[C@H](CC)[C@@H](O[C@]4([H])OC(C)(C)C(OC(C(C)C)=O)[C@H](O)[C@@H]4O)/C(C)=C\C(C)=C/C[C@]([C@H](O)C)([H])O1. InChi Code: InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,1. InChi Key: ZVGNESXIJDCBKN-KXVGEYJXSA-N.