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Product information "Colistin sulfate (Ph.Eur. Grade)"
White to off-white powder. Soluble in water. Very potent polymyxin antibiotic, Has only one amino acid difference compared to polymyxin B, Antimicrobial, Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death, Used against multidrug-resistant Gram-negative bacterial infections.
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