Chrysophanol

Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 µM. Chrysophanol (5, 10, and 50 µM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-kappaB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).Formal Name: 1,8-dihydroxy-3-methyl-9,10-anthracenedione. CAS Number: 481-74-3. Synonyms: Chrysophanic Acid, NSC 37132, NSC 646567, Turkey Rhubarb. Molecular Formula: C15H10O4. Formula Weight: 254.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/mL, DMSO: 0.2 mg/mL. lambdamax: 225, 257, 277, 287, 428 nm. SMILES: CC1=CC2=C(C(O)=C1)C(C3=C(O)C=CC=C3C2=O)=O. InChi Code: InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3. InChi Key: LQGUBLBATBMXHT-UHFFFAOYSA-N. Origin: Plant/Rheum palmatum.