Ceftazidime (hydrate)

Ceftazidime is a cephalosporin antibiotic. It is active against isolates of numerous Gram-positive and Gram-negative bacteria, including E. coli, K. pneumoniae, P. mirabilis, and S. pyogenes (MICs = 0.015-8 µg/ml for all). It binds to E. coli penicillin-binding protein 1a (PBP1a), -1b, -2, and -3 (IC50s = 0.9, 3.4, 240, and 0.06 µg/ml, respectively). Ceftazidime increases survival in mice infected with strains of S. aureus, E. coli, K. pneumoniae, Proteus, or Serratia (ED50s = 0.1-25 mg/kg for all). Formulations containing ceftazidime have been used in the treatment of bacterial infections.Formal Name: 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-pyridinium, pentahydrate. CAS Number: 78439-06-2. Molecular Formula: C22H22N6O7S2 . 5H2O. Formula Weight: 636.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=C(C1NC(/C(C2=CSC(N)=N2)=N\OC(C)(C)C(O)=O)=O)N3[C@]1([H])SCC(C[N+]4=CC=CC=C4)=C3C([O-])=O.O.O.O.O.O. InChi Code: InChI=1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27,,,,,/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34),5*1H2/b26-13-,,,,,/t14?,18-,,,,,/m1...../s1. InChi Key: NMVPEQXCMGEDNH-IPHVXHCQSA-N.