Besifloxacin (hydrochloride)

Besifloxacin is an ophthalmologic fluoroquinolone antibiotic that is active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 µg/ml). It inhibits LPS-stimulated production of the inflammatory cytokines IL-1beta, IL-8, IL-6, and IL-1alpha in human THP-1 monocytes. Besifloxacin, when 2 drops of a 0.6% solution are applied per eye, yields a concentration of 2 µg/g which is greater than the MIC90s of ophthalmologic isolates of H. influenzae, S. pneumoniae, S. aureus, and Corynebacterium and reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endophthalmitis.Formal Name: 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride. CAS Number: 405165-61-9. Synonyms: BOL-303224-A. Molecular Formula: C19H21ClFN3O3 . HCl. Formula Weight: 430.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: 1 mg/mL*. SMILES: FC1=CC2=C(C(Cl)=C1N3C[C@H](N)CCCC3)N(C4CC4)C=C(C(O)=O)C2=O.Cl. InChi Code: InChI=1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23,/h7,9-11H,1-6,8,22H2,(H,26,27),1H/t10-,/m1./s1. InChi Key: PMQBICKXAAKXAY-HNCPQSOCSA-N.