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![Amphotericin B](https://www.biomol.com/media/image/7c/3a/4a/Cay11636-1_600x600.png)
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Amphotericin B is a classic antifungal polyene macrolide that has been used in the treatment of... more
Product information "Amphotericin B"
Amphotericin B is a classic antifungal polyene macrolide that has been used in the treatment of systemic fungal infections, primarily caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures. Amphotericin B binds with ergosterol, the main component of fungal cell membranes, forming a transmembrane channel that results in altered plasma membrane permeability and leakage of vital cytoplasmic components, such as K+, ultimately inducing cell death. Because prolonged use of amphotericin B is associated with infusion-related events and nephrotoxicity, lipid-based formulations have been devised for more favorable clinical relevance.Formal Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid. CAS Number: 1397-89-3. Synonyms: LNS-AmB, NSC 527017. Molecular Formula: C47H73NO17. Formula Weight: 924.1. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 2 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 227, 283, 346, 364, 383,407 nm. SMILES: O=C1O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@](O3)([H])[C@H](C(O)=O)[C@@H](O)C[C@@]3(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1. InChi Code: InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,6. InChi Key: APKFDSVGJQXUKY-INPOYWNPSA-N.
Keywords: | Abelcet(R), AmBisome(R), Ampho-Moronal(R), Amphocin(R), Amphozone(R), Fungilin(R), Fungizone(R), Halizon(R), LNS-AmB, NSC 527017, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranos |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11636 |
Properties
Application: | Antibiotic, Antifungal polyene macrolide |
MW: | 924.1 D |
Formula: | C47H73NO17 |
Purity: | >90% |
Format: | Crystalline Solid |
Database Information
CAS : | 1397-89-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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