Aclarubicin

Aclarubicin is an anthracycline originally isolated from Streptomyces and has antibiotic and anticancer activities. It is active against B. subtilis, B. cereus, S. aureus, M. smegmatis, S. pyogenes, and S. faecalis (MICs = 50 = 0.12 µg/ml) and increases survival in an L1210 murine leukemia model when administered at a dose of 1.5 mg/kg per day.Formal Name: (1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid, methyl ester. CAS Number: 57576-44-0. Synonyms: NSC 208734. Molecular Formula: C42H53NO15. Formula Weight: 811.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 230, 260, 433 nm. SMILES: O=C1C2=C(C(C3=CC=CC(O)=C31)=O)C=C(C4=C2O)[C@H]([C@](CC)(O)C[C@@H]4O[C@@]5(O[C@@H](C)[C@@H](O[C@]6([H])O[C@@H](C)[C@@H](O[C@@]7([H])CCC([C@H](C)O7)=O)[C@@H](O)C6)[C@@H](N(C)C)C5)[H])C(OC)=O. InChi Code: InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+/m0/s1. InChi Key: USZYSDMBJDPRIF-SVEJIMAYSA-N. Origin: Bacterium/Streptomyces sp..