TL1A-Responsive Luciferase Reporter Jurkat Cell Line

TNF-like ligand 1A (TL1A)-Responsive Luciferase Reporter Jurkat Cell Line is a TL1A-responsive DR3/NF-kB luciferase reporter Jurkat cell line expressing firefly luciferase under the control of an NF-kB response element, and with stable expression of human DR3 (death receptor 3, TNFRSF25, NM_003790.3). Expression of the firefly luciferase gene is driven by NF-kB response elements located upstream of the minimal TATA promoter. Activation of the NF-kB signaling pathway by DR3 ligand TL1A (TNF-like Protein 1A, TNFSF15) can be monitored by measuring luciferase activity. This cell line has been validated for stimulation by TL1A.