NaV1.7 - HEK293 recombinant human stable cell line (2x10(6) cells)

Nav1.7 (Genbank # Q15858) is present at the endings of pain-sensing nerves, the nociceptors, close to region where the impulse is initiated. The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed reduced response to inflammatory pain. A synthetic codon-optimized DNA sequence encoding human NaV1.7 protein [2] with C-terminal Streptavidin-Binding Peptide (SBP) [3] tag is stably integrated in 293HEK-Trex cells. Application: Drug compound screening, Functional assays, Efficient antigen for mouse immunization. References:1. Catterall, W.A. Cell and Developmental Biology 16: 521-555 (2000). 2. Choi, J.S., et al. Neurology 67:1563-1567 (2006). 3. Li, Y., el al. Protein Science 20 (1): 140-149 (2011).