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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-82163 | 2 vials | - | - |
3 - 15 business days* |
15,179.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The FcRn: IgG Recycling HMEC-1 Cell Pool is a HMEC-1 cell pool expressing Fc gamma receptor and... more
Product information "FcRn: IgG Recycling HMEC-1 Cell Pool"
The FcRn: IgG Recycling HMEC-1 Cell Pool is a HMEC-1 cell pool expressing Fc gamma receptor and transporter (FCGRT) (NM_004107.5) and beta-2-microglobulin (B2M) (NM_004048.4), separated by a T2A self-cleaving peptide, under the control of a CMV promoter, introduced into HMEC-1 cells via lentiviral transduction. This cell pool is designed to measure the uptake and recycling of human IgG antibodies (human FcRn does not bind mouse IgG). This cell pool has been validated with Nivolumab, Rituximab, Trastuzumab, anti-PCSK9 and an anti-IL-2Ra antibody. Figure 1: Illustration of FcRn: IgG Recycling HMEC-1 Cell Pool mechanism of IgG FcRn-mediated recycling. Cells are incubated with an antibody (IgG) of interest in a low pH Dilution Buffer, allowing FcRn to bind to IgG. Cells are then washed, and IgG recycling can be analyzed after 24 hours
| Keywords: | FcRn, FCRN, FCGRT, Neonatal Fc receptor, IgG receptor FcRn large subunit p51, IgG Fc fragment receptor transporter alpha chain, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 82163 |
Properties
| Application: | FcRn IgG recycling inhibitor screening |
| Species reactivity: | human |
Database Information
| KEGG ID : | K24019 | Matching products |
| UniProt ID : | P55899 | Matching products |
| Gene ID : | GeneID 2217 | Matching products |
Handling & Safety
| Storage: | Liquid nitrogen |
| Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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