BAFF/APRIL Responsive BCMA-NF-kappaB Luciferase Reporter HEK293 Cell Line

The BCMA / NF-kappaB - HEK293 recombinant cell line has been transfected with full-length human BCMA cDNA (Genbank #NM_001192) under control of a CMV promoter for high constitutive expression. The NF-kappaB-luciferase reporter is also stably integrated into the genome. The firefly luciferase gene is controlled by four copies of the NF-kappaB Response Element upstream of a minimal promoter. Upon ligand binding, active BCMA will initiate the NF-kappaB signaling pathway, leading to expression of the NF-kappaB-controlled luciferase reporter.