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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-RTES00874.96 | 96 assays | - |
9 - 20 business days* |
534.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ELISA Type: Sandwich. Sensitivity: 9.375pg/mL. Range: 15.625--1000pg/mL. Protein function:... more
Product information "Rat NFE2L2 (Nuclear Factor, Erythroid Derived 2 Like Protein 2) ELISA Kit"
ELISA Type: Sandwich. Sensitivity: 9.375pg/mL. Range: 15.625--1000pg/mL. Protein function: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:16314513). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes. The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes. May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. [The UniProt Consortium]
Keywords: | NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor, erythroid derived 2, like 2, Nuclear factor erythroid 2-related factor 2 |
Supplier: | Assay Genie |
Supplier-Nr: | RTES00874 |
Properties
Application: | Sandwich ELISA |
Species reactivity: | rat |
Format: | Solid Phase |
Database Information
KEGG ID : | K05638 | Matching products |
UniProt ID : | O54968 | Matching products |
Gene ID : | GeneID 83619 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H315, H319 |
P Phrases: | P264, P280 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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