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![Porcine IL10 ELISA Kit](https://www.biomol.com/media/image/cf/39/10/ARG83026-96_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG83026.96 | 96 wells | - | - |
6 - 14 business days* |
750.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system... more
Product information "Porcine IL10 ELISA Kit"
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines including granulocyte-macrophage colony- stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G- CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co- stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Keywords: | IL10, CSIF, CSIF, IL-10, IL-10, Interleukin-10, Interleukin-10, Cytokine synthesis inhibitory factor, Cytokine synthesis inhibitory factor |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG83026 |
Properties
Application: | ELISA |
Species reactivity: | swine |
Format: | Solid Phase |
Database Information
KEGG ID : | K05443 | Matching products |
UniProt ID : | P22301 | Matching products |
Gene ID | GeneID 3586 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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