Porcine IL10 ELISA Kit

Porcine IL10 ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG83026.96 96 wells - -

6 - 14 business days*

750.00€
 
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system... more
Product information "Porcine IL10 ELISA Kit"
Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines including granulocyte-macrophage colony- stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G- CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co- stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Keywords: IL10, CSIF, CSIF, IL-10, IL-10, Interleukin-10, Interleukin-10, Cytokine synthesis inhibitory factor, Cytokine synthesis inhibitory factor
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG83026

Properties

Application: ELISA
Species reactivity: swine
Format: Solid Phase

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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