Pig High mobility group protein B1 (HMGB1) ELISA kit

Pig High mobility group protein B1 (HMGB1) ELISA kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CSB-EL010553PI.48 48 tests (48T) -

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682.00€
CSB-EL010553PI.96 96 tests (96T) -

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1,039.00€
CSB-EL010553PI.480 480 tests (5×96T) -

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3,587.00€
CSB-EL010553PI.960 960 tests (10×96T) -

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6,868.00€
 
Sample Types: serum, plasma, tissue homogenates Detection Range: 0.312 ng/mL-20 ng/mL... more
Product information "Pig High mobility group protein B1 (HMGB1) ELISA kit"
Sample Types: serum, plasma, tissue homogenates Detection Range: 0.312 ng/mL-20 ng/mL Sensitivity: 0.078 ng/mL Assay Principle: quantitative Measurement: SandwichAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins. [The UniProt Consortium]
Keywords: HMG1, HMG-1, HMGB1, High mobility group protein 1, High mobility group protein B1
Supplier: Cusabio
Supplier-Nr: EL010553PI

Properties

Application: ELISA, Sandwich ELISA
Species reactivity: swine
Format: Solid Phase

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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