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Track device being used
![Naveni PD1/PD-L1 HRP](https://www.biomol.com/media/image/e9/bc/67/NAV-NPT-PDL1-HRP-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NAV-NPT.PDL1.HRP.100 | 1 kit (4 mL, 100 rxns) | - |
7 - 10 business days* |
2,664.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Naveni PD1/PD-L1 is an in situ proximity ligation assay kit for chromogenic (HRP) detection... more
Product information "Naveni PD1/PD-L1 HRP"
The Naveni PD1/PD-L1 is an in situ proximity ligation assay kit for chromogenic (HRP) detection of the interaction of PD1 and PD-L1. This is the first commercial assay for detecting the interaction in situ, the kit gives a high signal-to-noise ratio and has an out-standing specificity. The kit has been validated on FFPE human tissue samples. For research use only. Not for use in diagnostic procedures. Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium]
Keywords: | Anti-hPD-1, Anti-CD279, Anti-Protein PD-1, Anti-Programmed cell death protein 1 |
Supplier: | Navinci |
Supplier-Nr: | NPT.PDL1.HRP.100 |
Properties
Application: | PLA |
Format: | Solid Phase |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q15116 | Matching products |
Gene ID | GeneID 5133 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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