Human SPTLC1 (Serine palmitoyltransferase 1) ELISA Kit (HUFI06344)

Human SPTLC1 (Serine palmitoyltransferase 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human SPTLC1 (Serine palmitoyltransferase 1) in serum, plasma & cell culture supernatant samples. The Human SPTLC1 (Serine palmitoyltransferase 1) ELISA Kit accurately measures natural Human SPTLC1 (Serine palmitoyltransferase 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human SPTLC1 (Serine palmitoyltransferase 1) peptide. Protein function: Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). Required for adipocyte cell viability and metabolic homeostasis. [The UniProt Consortium]