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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-HUFI03063.96 | 96 assays | - |
9 - 20 business days* |
641.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Protein kinase which is involved in the control of centrosome separation and... more
Product information "Human NEK2(Serine/threonine-protein kinase Nek2) ELISA Kit"
Protein function: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC, SGO1, NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). [The UniProt Consortium]
Keywords: | NEK2, NEK2A, HSPK 21, EC=2.7.11.1, NimA-like protein kinase 1, NimA-related protein kinase 2, Never in mitosis A-related kinase 2, Serine/threonine-protein kinase Nek2 |
Supplier: | Assay Genie |
Supplier-Nr: | HUFI03063 |
Properties
Database Information
KEGG ID : | K20872 | Matching products |
UniProt ID : | P51955 | Matching products |
Gene ID : | GeneID 4751 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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