Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) ELISA Kit (HUFI05291)

Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) in serum, plasma & cell culture supernatant samples. The Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) ELISA Kit accurately measures natural Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human ERAP1 (Endoplasmic reticulum aminopeptidase 1) peptide. Protein function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. [The UniProt Consortium]