Human EGFR ELISA Kit

Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance. {ECO:0000250, UniProtKB:Q01279, ECO:0000269, PubMed:10805725, ECO:0000269, PubMed:11116146, ECO:0000269, PubMed:11483589, ECO:0000269, PubMed:11602604, ECO:0000269, PubMed:12297049, ECO:0000269, PubMed:12297050, ECO:0000269, PubMed:12620237, ECO:0000269, PubMed:12873986, ECO:0000269, PubMed:15374980, ECO:0000269, PubMed:15590694, ECO:0000269, PubMed:15611079, ECO:0000269, PubMed:17115032, ECO:0000269, PubMed:17909029, ECO:0000269, PubMed:19560417, ECO:0000269, PubMed:20462955, ECO:0000269, PubMed:20837704, ECO:0000269, PubMed:21258366, ECO:0000269, PubMed:27153536, ECO:0000269, PubMed:2790960, ECO:0000269, PubMed:7679104, ECO:0000269, PubMed:8144591, ECO:0000269, PubMed:9419975}. [The UniProt Consortium]