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Track device being used
![Human CD223 / LAG3 ELISA Kit](https://www.biomol.com/media/image/e2/1c/f0/ARG83012-96_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG83012.96 | 96 wells | - | - |
6 - 14 business days* |
750.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated... more
Product information "Human CD223 / LAG3 ELISA Kit"
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II), the precise role of MHC-II-binding is however unclear (PubMed:8647185). {ECO:0000250, UniProtKB:Q61790, ECO:0000269, PubMed:20421648, ECO:0000269, PubMed:7805750, ECO:0000269, PubMed:8647185}. [The UniProt Consortium]
Keywords: | FDC, CD223, LAG-3 {ECO:0000303|PubMed:1692078}, sLAG-3 {ECO:0000250|UniProtKB:Q61790}, Secreted lymphocyte activation gene 3 protein {ECO:0000305}, Lymphocyte activation gene 3 protein {ECO:0000303|PubMed:1692078} |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG83012 |
Properties
Application: | ELISA |
Species reactivity: | human |
Format: | Solid Phase |
Database Information
KEGG ID : | K06565 | Matching products |
UniProt ID : | P18627 | Matching products |
Gene ID | GeneID 3902 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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