Human CD223 / LAG3 ELISA Kit

Human CD223 / LAG3 ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG83012.96 96 wells - -

6 - 14 business days*

750.00€
 
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated... more
Product information "Human CD223 / LAG3 ELISA Kit"
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II), the precise role of MHC-II-binding is however unclear (PubMed:8647185). {ECO:0000250, UniProtKB:Q61790, ECO:0000269, PubMed:20421648, ECO:0000269, PubMed:7805750, ECO:0000269, PubMed:8647185}. [The UniProt Consortium]
Keywords: FDC, CD223, LAG-3 {ECO:0000303|PubMed:1692078}, sLAG-3 {ECO:0000250|UniProtKB:Q61790}, Secreted lymphocyte activation gene 3 protein {ECO:0000305}, Lymphocyte activation gene 3 protein {ECO:0000303|PubMed:1692078}
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG83012

Properties

Application: ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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