Human CASP1 (Caspase 1) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of CASP1 in serum, plasma and other biological fluids. Detection Range: 78.13--5000pg/mL. Sensitivity: 46.88pg/mL. Protein function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive (PubMed:28314590). [The UniProt Consortium]