Human ADP-HMW (High Molecular Weight Adiponectin) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of ADP-HMW in serum, plasma and other biological fluids. Detection Range: 6.25--400ng/mL. Sensitivity: 3.75ng/mL. Protein function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. [The UniProt Consortium]