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![Human 12-LO (Arachidonate 12-Lipoxygenase) CLIA Kit](https://www.biomol.com/media/image/23/71/79/G-HUES01277-96_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-HUES01277.96 | 96 assays | - |
9 - 20 business days* |
694.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ELISA Type: CLIA. Sensitivity: 37.5 pg/mL. Range: 62.5--4000 pg/mL. Protein function: Catalyzes... more
Product information "Human 12-LO (Arachidonate 12-Lipoxygenase) CLIA Kit"
ELISA Type: CLIA. Sensitivity: 37.5 pg/mL. Range: 62.5--4000 pg/mL. Protein function: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids. Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy- docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy- DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009). [The UniProt Consortium]
Keywords: | 12LO, ALOX12, 12S-LOX, EC=3.3.2.-, 12S-lipoxygenase, Lipoxin synthase 12-LO, Linoleate 13S-lipoxygenase, Platelet-type lipoxygenase 12, Arachidonate 15-lipoxygenase,15S-type, Arachidonate 12-lipoxygenase, 12S-type |
Supplier: | Assay Genie |
Supplier-Nr: | HUES01277 |
Properties
Application: | CLIA |
Species reactivity: | human |
Format: | Solid Phase |
Database Information
KEGG ID : | K00458 | Matching products |
UniProt ID : | P18054 | Matching products |
Gene ID | GeneID 239 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319 |
P Phrases: | P264, P280 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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