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Product information "DNA/RNA Oxidative Damage (Clone 7E6.9) ELISA Kit"
DNA and RNA are damaged by oxidation during aging and in a variety of disease states including cancer. Guanine is the base is most prone to oxidation, and the repair processes initiated to correct the damage release multiple oxidized guanine species into the urine, including 8-hydroxyguanosine (8-OHG), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-hydroxyguanine. Some commercial vendors offer immunoassays that detect only 8-OHdG. Cayman's DNA/RNA Oxidative Damage (Clone 7E6.9) ELISA Kit is a competitive assay that can be used to measure both 8-OHdG and 8-OHG. Since the antibody used in the assay recognizes damaged nucleic acid species other than 8-OHdG, the value obtained with our assay will be higher than that obtained by competitor ELISAs or by LC/MS analysis that measure a single species. As such, caution is recommended when comparing results obtained from this kit to those obtained by other methods.Synonyms: DNA/RNA Oxidative Damage (Clone 7E6.9) EIA Kit, 8-Hydroxyguanosine, 8-OHG. Assay Range: 0.15-20 ng/ml. Sensitivity: 80% B/B0: 0.45 ng/ml. Mid-point: 50% B/B0: 1.25-1.75 ng/ml. Cross Reactivity: (8-hydroxy-2'-deoxyguanosine) 100%, (8-hydroxyguanosine) 100%, (8-hydroxyguanine) 0.15%, (Guanine) <0.1%, (Guanosine) <0.1%. Origin: Animal/Bovine, Animal/Eel, Animal/Mouse.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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