Chicken Insulin-like growth factors 1, IGF-1 ELISA Kit

Sample Types: serum, plasma, tissue homogenates Detection Range: 125 pg/mL-2000 pg/mL Sensitivity: 125 pg/mL Assay Principle: quantitative Measurement: CompetitiveAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. [The UniProt Consortium]