Caspase-1 (mouse) BioAssay(TM) ELISA Kit (Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-co

Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals. This Caspase-1 (mouse) ELISA Kit can be used to measure caspase-1 (mouse) in cell culture supernatants. It is a quantitative detection method, alternative to Western blotting to measure caspase-1 secretion. , Sensitivity:, 33pg/ml, Range: 0.15-10ng/ml, Sample Type: Cell Culture Supernatant, Plasma, Serum, Assay Type: Sandwich, Detection Type: Colorimetric, Specificity: Detects mouse caspase-1 (proform as well as p10 and p20 domain). Does not detect human caspase-1. Storage and Stability: Short-term Storage: +4°C, Long-term Storage: +4°C, 12 months after the day of manufacturing. See expiry date on ELISA Kit box.