Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) ELISA Kit (CNFI00064)

Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) in serum, plasma & cell culture supernatant samples. The Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) ELISA Kit accurately measures natural Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Canine NT-proANP (N-Terminal proAtrial Natriuretic Peptide) peptide. Protein function: [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses. Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance. Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts. Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension. In adipose tissue, acts in various cGMP- and PKG- dependent pathways to regulate lipid metabolism and energy homeostasis. This includes upregulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue. Binds the clearance receptor NPR3 which removes the hormone from circulation. [The UniProt Consortium]