Bovine CD8A (cell surface glycoprotein CD8 alpha chain) ELISA Kit (BOFI00139)

Bovine CD8A (cell surface glycoprotein CD8 alpha chain) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Bovine CD8A (cell surface glycoprotein CD8 alpha chain) in serum, plasma & cell culture supernatant samples. The Bovine CD8A (cell surface glycoprotein CD8 alpha chain) ELISA Kit accurately measures natural Bovine CD8A (cell surface glycoprotein CD8 alpha chain) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Bovine CD8A (cell surface glycoprotein CD8 alpha chain) peptide. Protein function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T- lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. [The UniProt Consortium]