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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32098-100 | 100 µg | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays... more
Product information "Anti-IgG3 (mouse) Rabbit Monoclonal Antibody (Clone RM218)"
Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response. It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in human and mouse serum. IgG consists of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each. The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively. IgG exists as four isotypes in mice: IgG1, IgG2b, IgG3, and, in a strain-specific manner, IgG2a or IgG2c. IgG3 production is driven by bacterial- or viral-associated antigens, including HIV-1 and Staphylococcus antigens, and occurs early in the immune response following IgM class-switching. IgG3 binds to and neutralizes pathogens, as well as activates complement and opsonizes bacteria, leading to complement-dependent cytotoxicity (CDC) and antibody-dependent cell cytotoxicity (ADCC), respectively. Serum IgG3 levels are increased in patients with primary biliary cirrhosis, Sjögren's syndrome, systemic sclerosis, or systemic lupus erythematosus (SLE). Cayman's IgG3 (mouse) Rabbit Monoclonal Antibody (Clone RM218) can be used for ELISA and Western blot (WB) applications. The antibody recognizes the Fab region of IgG3 from mouse samples.Synonyms: Immunoglobulin G3. Immunogen: Mouse IgG3. Clone Designation: RM218. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: WB, ELISA. Cross Reactivity: (-) Mouse IgG1, (-) IgG2a, (-) IgG2b, (-) IgM, (-) IgA, (-) IgE, (-) Human IgG, (-) Rat IgG.
Keywords: | Immunoglobulin G3 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32098 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | RM218 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse |
Immunogen: | Mouse IgG3 |
Format: | Purified |
Database Information
UniProt ID : | P03987 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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