Anti-Human IgM

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABS-KC-076.50 50 µl - -

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232.00€
ABS-KC-076.100 100 µl - -

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332.00€
 
Protein function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as... more
Product information "Anti-Human IgM"
Protein function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B- cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). [The UniProt Consortium]
Keywords: Anti-Immunoglobulin heavy constant mu, Anti-Ig mu chain C region, Anti-Ig mu chain C region BOT, Anti-Ig mu chain C region GAL, Anti-Ig mu chain C region OU, Anti-Human IgM Antibody
Supplier: Absea
Supplier-Nr: KC-076

Properties

Antibody Type: Monoclonal
Clone: KT194
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human IgM
Format: Solution

Database Information

UniProt ID : P01871 | Matching products

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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