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Track device being used
![Anti-phospho-RIPK1 / RIP1 (Ser161)](https://www.biomol.com/media/image/56/73/4e/ARG66649-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG66649.100 | 100 µl | - | - |
6 - 14 business days* |
624.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals... more
Product information "Anti-phospho-RIPK1 / RIP1 (Ser161)"
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF- alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512). [The UniProt Consortium]
Keywords: | Anti-phospho-RIP, Anti-phospho-RIPK1, Anti-phospho-RIP-1, Anti-phospho-Cell death protein RIP, Anti-phospho-Receptor-interacting protein 1, Anti-phospho-Receptor-interacting serine/threonine-protein kinase 1 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG66649 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse |
Immunogen: | Phosphospecific peptide around Ser161 of Human RIPK1 / RIP1 |
MW: | 76 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K02861 | Matching products |
UniProt ID : | Q13546 | Matching products |
Gene ID | GeneID 8737 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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