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![Anti-phospho-PGC-1 alpha, (S571) (Peroxisome Proliferator Activated Receptor gamma Coactivator 1 al](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P3363-03C.100 | 100 µg | - | - |
3 - 19 business days* |
871.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PGC-1a is a 97-120kD member of the PGC-1 family of proteins. It is expressed in select cell... more
Product information "Anti-phospho-PGC-1 alpha, (S571) (Peroxisome Proliferator Activated Receptor gamma Coactivator 1 al"
PGC-1a is a 97-120kD member of the PGC-1 family of proteins. It is expressed in select cell types, including brown adipocytes, skeletal muscle and hepatocytes. PGC-1a participates in both RNA processing and transcriptional coactivation in conjunction with multiple nuclear hormone receptors such as PPARg, RAR and TR. Human PCG-1a is 798aa in length. It contains an LxxLL nuclear receptor binding motif aa144-148, one PPAR-g interaction domain aa293-339, two NLSs and an RNA binding/processing region aa566-710. PGC-1a activity is regulated by phosphorylation. AMPK is known to phosphorylate Thr178 and Ser539, promoting cotranscriptional activity. Conversely, Akt-mediated phosphorylation at Ser571 is reported to downregulate PGC-1a activity. This latter effect is achieved by an initial Ser571 phosphorylation, followed by GCN5 binding and subsequent PCG-1a acetylation that promotes PGC-1a dissociation from target gene promoters. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml using HeLa human cervical epithelial carcinoma cell line and Jurkat human acute T cell leukemia cell line treated with recombinant human IGF-1, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | P3363-03C |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic phosphopeptide corresponding to human PGC1a. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K07202 | Matching products |
UniProt ID : | Q9UBK2 | Matching products |
Gene ID | GeneID 10891 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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