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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
039038.200 | 200 µl | - | - |
3 - 19 business days* |
728.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Three isoforms of nitric oxide synthase (NOS) have been identified. All are homodimers with... more
Product information "Anti-phospho-nNOS (Ser1417) (NOS1, Nitric oxide synthase, brain, Constitutive NOS, NC-NOS, NOS type"
Three isoforms of nitric oxide synthase (NOS) have been identified. All are homodimers with subunits of 130-160 kDa. All have binding sites for NADPH, FAD, and FMN near the carboxyl terminus (the reductase domain), and binding sites for tetrahydrobiopterin (BH4) and heme near the amino terminus (the oxygenase domain). The reductase and oxygenase domains are linked by a calmodulin (CaM) binding site. Occupation of this site facilitates electron transfer from the cofactors in the reductase domain to heme during nitric oxide production. NOS catalyzes the conversion of arginine to citrulline and nitric oxide (NO). Neuronal nitric oxide synthase (nNOS, bNOS, cNOS, Type I) is associated with the post-synaptic density protein (PSD-95) in the neuronal membrane. In response to increased intracellular Ca2+, nNOS interacts with CaM. The Ca2+ CaM complex, in combination with BH4, binds to nNOS and induces its translocation from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by calcineurin initiates the production NO. NO activates guanylyl cyclase (GC) and activates the various cGMP regulated signaling pathways. nNOS is in activated by phosphorylation by protein kinase A (PKA) or protein kinase C (PKC). Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot blot 1:500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-phospho-bNOS, Anti-phospho-nNOS, Anti-phospho-NOS1, Anti-phospho-N-NOS, Anti-phospho-NC-NOS, Anti-phospho-NOS type I, Anti-phospho-Neuronal NOS, EC=1.14.13.39, Anti-phospho-Constitutive NOS, Anti-phospho-Nitric oxide synthase, brain |
Supplier: | United States Biological |
Supplier-Nr: | 039038 |
Properties
Application: | ELISA, Dot Blot |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Phospho-nNOS-S1417 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 1403~1432 amino acids surrounding S1417 of human nNOS. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K13240 | Matching products |
UniProt ID : | P29475 | Matching products |
Gene ID | GeneID 4842 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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